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Amygdalar abnormalities are sometimes reported, although findings are inconsistent.Cannabis use is associated with increased recruitment of task related areas, such as the dorsolateral prefrontal cortex, which is thought to reflect compensatory activity due to reduced processing efficiency.

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Heavy, long term exposure to marijuana may have biologically-based physical, mental, behavioral and social health consequences and may be "associated with diseases of the liver (particularly with co-existing hepatitis C), lungs, heart, and vasculature".

Light and moderate use of cannabis is not believed to increase risk of lung or upper airway cancer.

In some cases, cannabis can lead to dissociative states such as depersonalization Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory, psychomotor coordination, and concentration.

Some users may experience an episode of acute psychosis, which usually abates after six hours, but in rare instances, heavy users may find the symptoms continuing for many days.

Cannabis is mostly used recreationally or as a medicinal drug, although it may also be used for spiritual purposes.

In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65).

sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use.

Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.

These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease.

Although global abnormalities in white matter and grey matter are not associated with cannabis abuse, reduced hippocampal volume is consistently found.

Evidence for causing these cancers is mixed concerning heavy, long-term use.

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