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Genotyping for cytochrome P450 has been proposed for possible use in medical management of drug therapies including, but not limited to, antidepressants, antiepileptic, antipsychotics, barbituates, clopidogrel, opioid analgesics, proton pump inhibitors, tamoxifen or warfarin.
Recent advances in molecular biology have improved the understanding of genetic factors underlying many ADRs.
Moreover, the clinical- and cost-effectiveness of pre-prescription genotyping for CYP polymorphisms has not been established.
More investigation is needed before prospective CYP genotyping can become routine clinical practice”.
In addition to its role in pharmacokinetics, CYP2C9 contributes to the metabolism of fatty acids, prostanoids, and steroid hormones, and it may catalyze potentially toxic bioactivation reactions.
However, the current understanding of the role of CYP2C9 in biotransformation of endogenous signaling molecules and in drug toxicity is relatively meager.Individuals with a lack of functional activity in these enzymes should be treated with very low doses of drugs metabolized by the same enzyme to avoid excessive drug levels and thus toxic effects.In recent years, research has been focused on gene coding for drug targets.In the more frequent heterozygous carriers (genotype *1/*3), the clearances were between 40 and 75 %.In these cases in which individual dosages are derived from clinical drug effects, such as for oral anticoagulants, the pharmacogenetics-based dose adjustments showed a good correlation with the genotype-specific empirically derived doses.Whether you’re in the mood to watch a live pay-per-view event at no additional cost or simply kick back and watch the very best of Stone Cold vs.Tags: Adult Dating, affair dating, sex dating