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These micelles are self- assembling closed lipid monolayers with a hydrophobic core and a hydrophobic shell.
Liposomal-based nanocarriers are known to be prone to extreme challenges that are encountered in their development and overall stability.
Polyethylene Glycol (PEG) has been reported to increase the circulation times by affording them protection from opsonization .
In addition, strategies have to be designed in the initial phases to avoid the uptake of these nanocarriers by the Reticulo-Endothelial System (RES).
However, because of the diligent investigative research, a large number of clinical trials are underway with various antibody containing nanocarriers formulations.
One of the classic examples is liposomal Doxorubicin used to treat AIDSrelated Kaposi’s sarcoma and ovarian cancer which has undergone clinical approval [2,3].
Other drugs encapsulated in liposomes are currently undergoing clinical trials or have been approved for clinical use such as Daunoxome (Liposomal Doxorubicin) used to treat AIDS-related Kaposi’s sarcoma [4,5] or Depocyt (Liposomal Cytarabine) used to treat lymphomatous meningitis .Free drugs are known to diffuse non- specifically; however, nanoparticles accumulate at the specific target site with the aforementioned enhanced permeability and retention effect.With the aid of optimized targeting ligands on their surface, nanoparticles will be able to deliver the payload at the tumor site and even reduce its distribution to the peripheral tissues.As a result of the high surface area to volume ratio of these nanoparticles; it is quite possible to achieve high ligand density on the surface of these nanocarriers for active targeting purposes.Controlled release of the drug from these nanocarriers is another important parameter which determines the fate of drug in the body, once the drug-loaded nanocarriers are administered.Received Date: March 28, 2017; Accepted Date: March 30, 2017; Published Date: April 05, 2017 Citation: Wakaskar RR (2017) Cancer Therapy with Drug Delivery Systems. doi: 10.4172/2153-0645.100e158 Copyright: © 2017 Wakaskar RR.Tags: Adult Dating, affair dating, sex dating